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Although the exact cause of death has not been elucidated, in comparison to the control group, changes in behavioral patterns (decreased activity, prostration, unkempt appearance, etc.) that persisted for several hours after SNAC administration

Clinicians should maintain a high index of suspicion for gastroparesis when patients report vomiting undigested food many hours after meals, severe refractory nausea despite antiemetic therapy, or inability to maintain adequate oral intake

In these cases, switching to a different glucose-lowering agent or stopping metformin altogether may improve tolerability

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